研究硝酸酯药物后处理对大鼠缺血再灌注损伤的心肌保护作用。
Tostudyprotectiveeffectofnitratespharmacologicalpostconditioning(PI-PostC)onischemia-reperfusion(I/R)injuredmyocardiuminrats.
Wistar大鼠32只随机分为假手术组、缺血再灌注组(I/R组)、后处理组(IPostC组)及硝酸酯后处理组(PI-PostC组),每组8只。分别测定各组缺血和梗死心肌面积、血浆心肌肌钙蛋白I(cTnI)水平和细胞凋亡指数,并进行比较。
Atotalof32Wistarratswererandomlyandequallydividedintoshamoperationgroup,I/Rgroup,ischemiapostconditioninggroup(IPostCgroup)andPI-PostCgroup.Myocardialischemicarea,infractsize,plasmalevelofcardiactroponinI(cTnI)andcellapoptoticindexweremeasuredand